Chemical Libraries

BioMol Libraries

Bioactive lipids, 204 compounds. endo-cannabinoid, 60 compounds, ion channel, 72 compounds, enzyme inhibitors, 84 compounds and phosphatase and kinase inhibitors, orphan ligands, 84 compounds. This library serves primarily for assay validation.

FDA Approved Drug Library

A unique collection of 1120 high-purity chemical compounds (all off patent)
carefully selected for:

• Structural diversity
• Broad spectrum covering several therapeutic areas
  (from neuropsychiatry to cardiology, immunology,
  anti-inflammatory, analgesia and more)
• Known safety and bioavailability in humans

Microsource Spectrum Collection

2000 biologically active and structurally diverse compounds from our libraries of known drugs, experimental bioactives, and pure natural products.

Druggable Compound Set

A set of about 8000 compounds which are targeted at kinases, protease, ion channels and GPCR's. These compounds are designed to match our siRNA efforts which are based on sets of siRNA's for the druggable human and mouse genome.

Lead Like Compound Set

This set of 20,000 compounds has been custom tailored for us for lead likeness. The compounds in this set are not to be found in any of the traditional "Russian" collections.

Chemically Diverse Libraries (Combichem Library)

ChemBridge DiverSet, 30,000 chemically diverse small molecules.

A custom set of 20,000 compounds which have been selected for low cellular toxicity and excellent coverage of the chemical space.

A smart set of 40,000 compounds with excellent coverage of the chemical space selected from a set of over 600,000 compounds.

Another set of 50,000 compounds is currently in the works.

UCLA in-house Collection

Various professors have donated their compounds to our in-house collection and so far we have collected about 5000 compounds. These libraires are extremely diverse and range from natural products to compounds which have been synthesized using diversity-oriented synthesis.

Functional Genomics Libraries

Arrayed siRNA Libraries

A human and mouse druggable genome wide collection is available for screening. The two libraries cover about 7,000 genes each. We have four siRNA's per target, which are screened in a non-pooled format. Kinases and GPCR's are available as sub-libraries.

Arrayed shRNA Library

Our arrayed shRNA libraries contain over 60,000 clones targeting about 18,000 genes with an emphasis in coverage on desirable target classes such as kinases, proteases, phosphatases, GPCRs and ion channels. In addition to the traditional target classes we offer various custom libraries such as a validated cancer specific shRNA set of about 150 targets from the NCI and a cancer specific set of over 2000 clones covering 500 cancer related genes selected by the Sanger Institute. Other sublibraries cover transcription factors, ubiquitinization and de-ubiquitinization pathways, apoptosis etc. These libraries are proprietary to the MSSR as they were custom selected and arrayed at the MSSR. The capability of customizing shRNA libraries enables the MSSR as well to tailor shRNA libraries to the needs of a particular Principle Investigator's laboratory.

Arrayed cDNA Library

A human and mouse mixed genome wide collection is available for screening. The libraries covers about 16,000 genes and is a consolidated version of the expressable clones from the MGC collection of full length cDNA clones. These clones are in the pSPORT6 expression vector which uses the CMV promotor to drive the expression of the insert. We can as well customize libraries to your requirements as needed.

Yeast Knockout Collection

A genome wide set of non-essential knockout mutants of yeast is available for screening in both mating types (alpha and A). The strain collections have been condensed into 384 well plates to facilitate high throughput screening. We have successfully used this library as well for synthetic genetic array screens.

E-Coli Knockout Collection

A genome wide set of non-essential knockout mutants of E-Coli is available for screening. The strain collections have been condensed into 384 well plates to facilitate high throughput.

E-Coli Promotor Collection

A set of about about 2000 E-Coli promotors with GFP as reporter gene is available for screening. The strain collections have been condensed into 384 well plates to facilitate high throughput screening.

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